jneuroJournal of Neurology and NeuropsychiatrycoVolume 3 Issue 1 (Jan-June)MultidisciplinaryEnglish6 Months NNY20260427NeurologyHuntington’s disease and Wilson’s disease in Sweden have a common origin in the 16th century and expanded due to effective family size of the founder familyEnglishY00Roman"EnglishNserif">K Sigvard Olsson1Olof Stenum2style="font-family:AptosEnglishYsans-serif">Roman"EnglishYserif">OlofWålinder3EnglishYSamratRoyChowdhury4EnglishYRumaRaha-Chowdhury5EnglishY6EnglishYHuntington´s disease (HD) is a neurodegenerative disorder first reported from Sweden in 1936 observed in a small river valley population. This population has recently been reported to be carrying a number of recessive disorders, such as, hereditary haemochromatosis (HH), Wilson´s Disease (WD), the long QT syndrome and autosomal recessive deafness (ARD). Whether the two neurodegenerative disorders, HD and WD, have a common origin is unclear. It was traced to a family born between 1579-1580, most probably succeeded by effective family size (EFS). HD haplotype studies have shown an ancestor born around 1610 in this family. Aims:  To test whether HD and WD had a common origin and whether their evolution was influenced by the EFS in the founder family around 1579-1580.  Methods: The surnames and date of birth were available for 40 HD families including 88 family members reported in 1936. Pedigrees were given in Cyrillic.Results: 35 of 40 HD families came from the pedigree of a founder couple in late 17th century and all but one individual had origin in a known WD/HH founder family born around 1620. The EFS had a strong impact on the HD/WD founder pedigree. The ARD-, HH- and LQTS-alleles were also present in these families. Conclusions:  Extensive genealogical studies of a small Swedish river valley population showed a common origin with a higher frequency of HD and WD, possibly because of EFS of the 1579-1580 founder family that also included HH, LQTS and ARD alleles. The epidemiological studies suggested that this gene pool migrated from the British islands possibly transmitted by the Vikings.EnglishEffective family size, Huntington´s disease, Wilson´s disease, autosomal recessive deafness (ARD), Hereditary haemochromatosis, Long QT Syndrome, Jervell and Lange-Nielsen syndrome (JLNS), river valley populations, Vikings, Church recordshttps://jneuro.clsconf.com/admin/abstract?id=38References1619